Daniel Kim

Phagocytosis of SARS-CoV-2 Nucleocapsid- and RNA-Containing Immune Complexes Drives Inflammatory Cytokine Production and Endothelial Dysfunction

This study investigates how SARS-CoV-2 RNA and nucleocapsid-containing immune complexes drive inflammation and endothelial dysfunction through Fcγ receptor and TLR-8 pathways.

Monounsaturated fatty acid biosynthesis is critical for streptococcal envelope homeostasis and stress tolerance

This study shows that monounsaturated fatty acid biosynthesis is essential for streptococcal growth, stress tolerance, and virulence, with species-specific effects on pathogenesis.

Pre-analytical delay as a dominant confounder in blood RNA-seq: Rapid ex vivo gene expression changes in EDTA blood

The paper investigates how pre-analytical delay affects gene expression in EDTA blood compared to stabilized PAXgene blood using RNA-seq.

Epigenomics identifies three sources of DNA methylation in Streptococcus mutans UA159

This study identifies three DNA methylation sources in Streptococcus mutans UA159 using Oxford Nanopore sequencing, revealing a novel methyltransferase and its functional roles in biofilm formation and microbial interactions.

Volumetric montaging of optical coherence tomography in human retinas

This paper introduces a method to increase the field of view in clinical OCT by volumetrically montaging multiple datasets, achieving ultrawide FOV imaging without hardware changes.

Seq-Scope-eXpanded: Spatial Omics Beyond Optical Resolution

Seq-Scope-X improves spatial transcriptomics resolution by expanding tissues, revealing detailed nuclear and cytoplasmic transcriptome differences in liver cells and enabling proteomic analysis in other tissues.

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemms Canal Anatomy and Segmental Pilocarpine Response

This paper uses robotic visible-light OCT to visualize segmental Schlemms canal anatomy and its response to pilocarpine in mice, showing segmental changes in volume.

In vivo quantification of anterior and posterior chamber volumes in mice: implications for aqueous humor dynamics

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

Engineering a super-secreting strain of Escherichia coli by directed co-evolution of the multiprotein Tat translocation machinery

The paper evolves Escherichia coli Tat translocases to enhance protein secretion, finding three variants that significantly increase periplasmic protein export compared to wildtype and SecYEG.

Systemically administered MSCs given 24hrs after osteotomy do not affect bone formation in rat distraction osteogenesis

This study investigates whether systemic administration of mesenchymal stem cells (MSCs) 24 hours after osteotomy affects bone formation in rat distraction osteogenesis, finding no significant differences in bone outcomes.