Gius Kerster

This study investigates how SARS-CoV-2 RNA and nucleocapsid-containing immune complexes drive inflammation and endothelial dysfunction through Fcγ receptor and TLR-8 pathways.

The paper evaluates adjuvant effects on immune responses in virosome-based SARS-CoV-2 vaccines, finding distinct impacts on humoral and cellular immunity.

The paper characterizes early antigen-specific B cell responses after vaccination, identifying distinct clusters with different contraction dynamics and potential roles in memory B cell formation.

This study defines the dynamic activation-memory cycle of human IgG memory B cells through single-cell profiling, revealing distinct reactivation trajectories and functional roles in humoral immunity.

This paper describes an experimental pipeline for generating human monoclonal antibodies against bacterial pathogens using synthetic glycan fragments, identifying functional antibodies against Staphylococcus aureus and Streptococcus pyogenes.

The paper identifies novel stages in IgG memory B cell and antibody-secreting cell differentiation by analyzing antigen-specific B cells from different pathogens using high-dimensional flow cytometry.