A novel inducible mtDNA mutator mouse model to study mitochondrial dysfunction with temporal and spatial control
Hannah Tobias-Wallingford, Sydney Bartman, Lauren Gaspar, Brian Gallagher, Carole Bassa, Emmanuel Sotirakis, Vincent Dubus, Christopher Hemme, Lars Olson, Giuseppe Coppotelli, Jaime M. Ross
This paper develops an inducible mtDNA mutator mouse model to study mitochondrial dysfunction with spatial and temporal control, showing it recapitulates the original model's phenotype.
Innovation in Aging · Dec 1, 2025Peer-reviewedGenetics