Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells
Megan R. Teh, Nancy Gudgeon, Joe N. Frost, Linda V. Sinclair, Alastair L. Smith, Christopher L. Millington, Barbara Kronsteiner, Jennie Roberts, Bryan P. Marzullo, Alexandra E. Preston, Jan Rehwinkel, Thomas A. Milne, Daniel A. Tennant, Susanna J. Dunachie, Andrew E. Armitage, , Hal Drakesmith
This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.
bioRxiv · Feb 1, 2024 · PreprintImmunology