Hal Drakesmith

This study identifies the transcriptional regulatory mechanisms governing ERFE expression in human erythroblasts using genomic approaches.

This study shows GSK-J4, a KDM6 inhibitor, induces metal and stress responses in multiple myeloma cells by increasing intracellular Zn2+ and activating metallothionein gene expression.

The paper quantifies cellular iron content in immune cells using sc-ICP-MS and finds cell-type and activation state-specific iron regulation.

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

The paper quantifies single-cell iron content in lymphocytes using ICP-MS and links iron levels to cellular activation and function.

This study shows that iron accumulates abnormally in the spinal cord of MS patients, correlating with oxidative stress and neurodegeneration, but not with demyelination or iron-rimmed lesions.

This study identifies Nprl3 as a key regulator of erythroid metabolism, showing its role in coupling metabolic and developmental processes during erythropoiesis.