Author
University of BirminghamORCID 0000-0002-1874-6906Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Stavroula Petridi, Abhilesh S Dhawanjewar, Dnyanesh Dubal…·Jelle van den Ameele
The paper shows that tissue-wide metabolic buffering allows neural stem cells to maintain proliferation despite mitochondrial dysfunction, highlighting the role of tissue heterogeneity in resilience.
Deborah Y. Moss, Connor N. Brown, Andrew M. Shaw…·Emma M. Kerr
This study identifies mitochondrial metabolism as a key factor in 5-fluorouracil resistance in colorectal cancer and shows that targeting mitochondrial Complex I can enhance chemotherapy effectiveness.
Mirko Milošević, Kristina Dmytruk, Ahmad Y. Alghadi…·Jakub Rohlena
This paper shows that asparagine enables transsulfuration to restore redox balance in tumors lacking aspartate synthesis enzymes, highlighting transsulfuration as a targetable vulnerability.
Samuel J Lara Reyna, Barbara Clough, Will M. Channell…·Eva‐Maria Frickel
This study identifies GBP5's role in enhancing glycolysis and maintaining Golgi integrity in IFNγ-stimulated macrophages.
Megan R. Teh, Nancy H. Gudgeon, Joe N. Frost…·Hal Drakesmith
This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.