An Innate Neuroprotective Reflex Activates NRF2 via Phosphorylation of p62 at Ser351 to Mitigate Traumatic Brain Injury
Chunyan Li, Keren Powell, Steven Wadolowski, David LeDoux, Amir R Dehdashti, Jamie S Ullman, Max Brenner, Christopher LeDoux, Kaitlyn Rams, Daniel Sciubba, Ping Wang
This paper shows that artificial diving reflex via trigeminal nerve stimulation activates NRF2 through p62 phosphorylation, offering neuroprotection in traumatic brain injury without depleting antioxidant reserves.
bioRxiv · Nov 4, 2026 · PreprintNeuroscience