Author

Christopher Weber

University Medical Center of the Johannes Gutenberg University Mainz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Anindita BasuiD· 1 shared Axel MethneriD· 1 shared Bernhard MichalkeiD· 1 shared Bingqing XieiD· 1 shared Candace M. ChamiD· 1 shared Eugene B. ChangiD· 1 shared Eva-Maria HanschmanniD· 1 shared Giuseppe ArenaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Anindita BasuORCID

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2 papers

Recent·Most cited

Mucosal ecosystems of the ileum and colon shape the therapeutic response in Crohn's Disease

Ran RZ Zhou, Bingqing Xie, Christopher Weber, Joel Pekow, Candace M. Cham, Jianqiao Liu, Yu Zhao, Jason Koval, Eugene B. Chang, Anindita Basu

The paper identifies non-responder-specific epithelial-stromal-immune ecosystems in Crohn's Disease using single-cell and spatial transcriptomics, linking them to treatment resistance.

bioRxiv · Mar 26, 2025 · PreprintImmunology

Iron-sulfur cluster loss in mitochondrial CISD1 mediates PINK1 loss-of-function phenotypes

Sara Bitar, Timo Baumann, Christopher Weber, Majd Abusaada, Liliana Rojas-Charry, Patrick Ziegler, Thomas Schettgen, Isabella Eva Randerath, Vivek Venkataramani, Bernhard Michalke, Eva-Maria Hanschmann, Giuseppe Arena, Rejko Krüger, Li Zhang, Axel Methner

The paper shows that CISD1 dimerization in PINK1 mutants disrupts iron-sulfur cluster coordination, leading to Parkinson's disease-like phenotypes, and suggests CISD1 as a therapeutic target.

eLife · Aug 19, 2024Peer-reviewedNeuroscience