Candace M. Cham

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

The paper investigates whether persistent inflammation in Crohn's disease is due to environmental triggers or intrinsic epithelial changes by comparing organoid and tissue data from patients in remission.

This study shows that a regular chow diet, not microbial transplant, enables rapid gut microbiome recovery after antibiotics in mice, and that diet is essential for effective fecal microbiota transplant.

The paper identifies non-responder-specific epithelial-stromal-immune ecosystems in Crohn's Disease using single-cell and spatial transcriptomics, linking them to treatment resistance.

The paper constructs a cell-type-resolved chromatin accessibility atlas in the human intestine and identifies regulatory programs and genetic variants associated with Crohn's disease.

This study shows that Bacteroides fragilis from UC patients promotes colitis in genetically susceptible mice, suggesting a role for pathobionts in IBD.

This paper identifies peptide YY (PYY) as a novel antimicrobial peptide produced by Paneth cells with selective antifungal activity against Candida albicans hyphae, maintaining gut fungal commensalism.