A cross-kingdom interactome predicted by AlphaFold3 reveals a DNF2-centered interface required for symbiotic accommodation
Jin‐Peng Gao, Feiyang Zhao, Guofeng Zhang, Qingchao Chen, Song Wu, Junfan Huang, Chun Liu, Guoliang Wang, Peng Yu, Sebastian Eves‐van den Akker, Chang Fu Tian, Thomas Ott, Jeremy D. Murray, Giles E. D. Oldroyd, Pengbo Liang, Chongjing Xia
The paper uses AlphaFold3 to predict a cross-kingdom interactome between Medicago truncatula and Sinorhizobium meliloti, identifying DNF2 as a key hub for host-symbiont communication.
bioRxiv · Sep 8, 2026 · PreprintPlant Biology