Qingchao Chen

This study identifies molecular mechanisms underlying β1-adrenoceptor selectivity of antagonists through cryo-EM structures, kinetic analysis, and MD simulations.

The paper shows that a second G protein couples with higher affinity to a GPCR dimer than the first, due to conformational stabilization by the first G protein.

GuideFlip co-designs protein structure and sequence for flexible targets, improving in silico success rates and experimentally validating binders to disordered proteins.

The paper uses AlphaFold3 to predict a cross-kingdom interactome between Medicago truncatula and Sinorhizobium meliloti, identifying DNF2 as a key hub for host-symbiont communication.

The paper determines the cryo-EM structure of ADGRL4 coupled to Gq, showing weak Gq coupling and distinct interactions compared to other GPCRs, supporting its role in cancer.

This paper presents computational methods for designing GPCR-binding miniproteins and validates them through high-throughput screening, producing agonists and antagonists for multiple GPCRs.

The paper determines the cryo-EM structure of mTAAR7f bound to DMCH, revealing its unique binding site and activation mechanism distinct from ORs.