Author

Chunke Chen

Chinese University of Hong Kong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:protein structure· 1

Frequent Co-Authors

Chris Ka Pun MokiD· 3 shared Huibin LviD· 3 shared Nicholas C. WuiD· 3 shared Akshita Baiju GopaliD· 2 shared Qi Wen TeoiD· 2 shared Tossapol PholchareeiD· 2 shared Yuanxin SuniD· 2 shared Yun Sang TangiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersImmunology

Chris Ka Pun MokORCID

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3 papers

Recent·Most cited

Antibodies targeting a conserved cryptic epitope at the influenza hemagglutinin head-stem interface via distinct binding modes

Guthrie L. Stroh, Huibin Lv, Chunke Chen, Yuanxin Sun, Tossapol Pholcharee, Catherine Zhu, Shu Ting Teo, Douglas A. Mitchell, Chris Ka Pun Mok, Nicholas C. Wu

This study characterizes two broadly reactive antibodies against a conserved cryptic epitope at the influenza HA head-stem interface, showing they are non-neutralizing and have limited protective efficacy.

bioRxiv · Oct 3, 2026 · PreprintBiochemistry

Somatic evolution of a cross-reactive germline antibody that expands its breadth to neutralize new SARS-CoV-2 variants

Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita Baiju Gopal, Danbi Choi, Timothy J.C. Tan, Yun Sang Tang, Lewis Yu-Lam Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris Ka Pun Mok

This study identifies a cross-reactive germline antibody that can be evolved to neutralize multiple SARS-CoV-2 variants through targeted somatic mutations.

bioRxiv · Mar 25, 2026 · PreprintImmunology

Evolution of antibody cross-reactivity to influenza H5N1 neuraminidase from an N2-specific germline

Huibin Lv, Yang Wei Huan, Qi Wen Teo, Chunke Chen, Tossapol Pholcharee, Akshita Baiju Gopal, Madison R. Ardagh, Jessica J. Huang, Ruipeng Lei, Xin Chen, Yuanxin Sun, Yun Sang Tang, Arjun Mehta, Mateusz Szlembarski, Kevin J. Mao, , Nicholas C. Wu

This study identifies an antibody that cross-reacts with H5N1 and H3N2 neuraminidases and shows how somatic hypermutation enables this cross-reactivity.

Cell Host & Microbe · Oct 18, 2025Peer-reviewedImmunology