An antibiotic that mediates immune destruction of senescent cancer cells
Gabriele Casagrande Raffi, Jian Chen, Xuezhao Feng, Zhen Chen, Cor Lieftink, Shuang Deng, Jinzhe Mo, Chuting Zeng, Marit Steur, Jing Wang, Onno B. Bleijerveld, Liesbeth Hoekman, Nicole N. van der Wel, Feng Wang, Roderick L. Beijersbergen, , Liqin Wang
This paper identifies SLC25A23 as a vulnerability in senescent cancer cells and shows that salinomycin induces immunogenic cell death, enhancing immune destruction of these cells when combined with a DR5 agonistic antibody.
Proceedings of the National Academy of Sciences · Dec 18, 2024Peer-reviewedCancer Biology