Feng Wang

ADP-ribose triggers neuronal ferroptosis by rewiring purine and pyrimidine metabolism

This study identifies ADP-ribose as a mediator of neuronal ferroptosis through metabolic rewiring, showing that blocking its signaling alleviates cognitive decline in mouse models.

Peroxisome quality control is gated by a dynamic ATF6α-ABCD3 tether

This paper identifies ATF6α as a non-transcriptional regulator of peroxisome quality control through its interaction with ABCD3, and shows how this interaction can be modulated by Ceapin to influence cancer-related processes.

Low-Density Lipoprotein Cholesterol and Cerebral Pericyte Dysfunction in Acute Ischemic Stroke: Clinical and Experimental Evidence

This study links LDL-C to cerebral pericyte dysfunction in acute ischemic stroke through clinical and experimental evidence, showing oxidative stress and type-I interferon signaling changes.

Superficial spinal Tac1-lineage neurons are polymodal nociceptive

This study characterizes the developmental and functional diversity of Tac1-lineage neurons in the spinal dorsal horn, showing they are polymodal nociceptive in adults.

Spinotrode: long-term intraspinal electrophysiological recordings to unravel dorsal horn neuron dynamics in behaving mice

The paper introduces Spinotrode, a vertebral implant for long-term single-cell recordings in the dorsal horns of behaving mice, revealing new insights into spinal neuron dynamics during natural behaviors.

CatIF-RL: Activity-Oriented Enzyme Sequence Design by Steered Inverse Protein Folding

CatIF-RL designs enzyme variants with enhanced catalytic activity by steering an inverse folding model using predicted kcat as an optimization objective.

A telomere-to-telomere (T2T) pig genome assembly reveals Y chromosome diversity and structural variations of Wuzhishan pigs

This study assembles a high-quality telomere-to-telomere genome of Wuzhishan pigs, revealing genetic diversity and structural variations compared to a previous assembly.

Insight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex

The paper determines the structure of the STAT2-USP18-ISG15 ternary complex using cryo-EM, revealing how USP18's scaffolding function suppresses IFN-I signaling by disrupting its enzymatic activity.

Disruption of the NTCP-EGFR receptor complex as a strategy for selective inhibition of hepatitis B and D virus entry

This study identifies Oxy229, a compound that disrupts the NTCP-EGFR receptor complex, selectively inhibiting HBV and HDV entry without affecting NTCP or EGFR physiological functions.

A neuronal pathway for the supraspinal relay of warm and cool sensation

The paper identifies a neuronal pathway in mice for relaying warm and cool sensations through the anterolateral tract, showing that specific neurons are tuned to innocuous temperature changes.

An antibiotic that mediates immune destruction of senescent cancer cells

This paper identifies SLC25A23 as a vulnerability in senescent cancer cells and shows that salinomycin induces immunogenic cell death, enhancing immune destruction of these cells when combined with a DR5 agonistic antibody.

A chemical probe to modulate human GID4 Pro/N-degron interactions

The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.

Assessing spontaneous sensory neuron activity using in vivo calcium imaging

This paper assesses spontaneous sensory neuron activity using in vivo calcium imaging and develops a machine learning algorithm to predict spontaneous activity with high accuracy across different pain models and labs.

The manipulation of spinal motor neuron axonal growth promotes spinal cord repair

This study shows that knocking out pten in mature spinal motor neurons enhances axonal regeneration and synaptic reconnection after spinal cord injury.

Deficient spermiogenesis in mice lacking Rlim

This study shows that Rlim is essential for spermiogenesis in male mice, as its deletion leads to defective sperm production and fertility issues.

More Severe Loss-of-Function Sodium Channel induced by Compound SCN5A R965C and R1309H Mutants lead to Complex Familial Arrhythmia Syndrome.

The paper identifies a compound SCN5A mutation R965C-R1309H in a family with arrhythmia syndrome, showing it causes more severe sodium channel dysfunction than either mutation alone.

Calcium/calmodulin-dependent protein kinase II regulates mammalian axon growth by affecting F-actin length in growth cone

This study shows that CaMKII regulates axon growth by modulating F-actin length in growth cones, with implications for axon regeneration in both peripheral and central nervous systems.

AGO4 is specifically required for heterochromatic siRNA accumulation at Pol V-dependent loci in Arabidopsis thaliana

This study shows AGO4 is required for specific heterochromatic siRNA accumulation in Arabidopsis, and its slicing activity is critical for this process.

Genome-Wide Analysis of Single Non-Templated Nucleotides in Plant Endogenous siRNAs and miRNAs

The paper analyzes non-templated nucleotides in plant small RNAs across multiple species, finding elevated rates at 3' ends of miRNAs and siRNAs in wild-type plants.