Novel synthetic ecteinascidins exhibit potent anti-melanoma activity by suppressing super-enhancer-driven oncogenic transcription
Max Cigrang, Julian Obid, Maguelone Nogaret, Léane Seno, Tao Ye, Guillaume Davidson, Philippe Catez, Pietro Berico, Clara Capelli, Clara Marechal, Amélie Zachayus, Clémence Elly, Marie Jose Guillen Navarro, Marta Martínez, Gema Santamaría Núñez, , Frédéric Coin
This study shows novel synthetic ecteinascidins effectively treat melanoma by inhibiting super-enhancer-driven oncogenic transcription, even in resistant models.
Nature Communications · Jan 8, 2025Peer-reviewedCancer Biology