Clara Capelli

A nuclear trafficking checkpoint licenses resolution of RNA-DNA hybrids at stalled RNAPII to maintain genome stability under genotoxic stress

The paper shows that genotoxic stress triggers nuclear import of EXD2 to resolve RNA-DNA hybrids at stalled RNAPII, preventing transcription-replication conflicts and maintaining genome stability.

Novel synthetic ecteinascidins exhibit potent anti-melanoma activity by suppressing super-enhancer-driven oncogenic transcription

This study shows novel synthetic ecteinascidins effectively treat melanoma by inhibiting super-enhancer-driven oncogenic transcription, even in resistant models.