Philippe Catez

A nuclear trafficking checkpoint licenses resolution of RNA-DNA hybrids at stalled RNAPII to maintain genome stability under genotoxic stress

The paper shows that genotoxic stress triggers nuclear import of EXD2 to resolve RNA-DNA hybrids at stalled RNAPII, preventing transcription-replication conflicts and maintaining genome stability.

Novel synthetic ecteinascidins exhibit potent anti-melanoma activity by suppressing super-enhancer-driven oncogenic transcription

This study shows novel synthetic ecteinascidins effectively treat melanoma by inhibiting super-enhancer-driven oncogenic transcription, even in resistant models.

Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress

The paper shows that EXD2 nuclease degrades nascent mRNAs during genotoxic stress, enabling transcription recovery after DNA repair.