Genome-Wide Polygenic Risk Score Identifies Individuals at Elevated Parkinson's Disease Risk
Yingnan Han, Erin A. Teeple, Srinivas Shankara, Mahdiar Sadeghi, Cheng Zhu, Dongyu Liu, FinnGen, Clarence Wang, Francesca Frau, Katherine Wood Klinger, Stephen L. Madden, Deepak K. Rajpal, S. Pablo Sardi, Dinesh Kumar
This paper computes a genome-wide polygenic risk score for Parkinson's Disease using 6.2 million variants and finds it strongly associates with increased disease risk and earlier onset.
medRxiv · Oct 16, 2020 · PreprintGenetic & Genomic Medicine