Deepak K. Rajpal

The paper identifies inverted D genes and D-D fusions in human antibody repertoires, revealing new diversity and functionality through a comprehensive analysis of NGS data.

This study identifies therapeutic targets by integrating GWAS with multi-omics data, finding enriched causal genes and novel associations like IL6ST in polymyalgia rheumatica.

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.

The paper profiles single nuclei from human putamen in Parkinson's Disease and Multiple System Atrophy, revealing disease-specific oligodendrocyte heterogeneity and gene expression changes.

The paper constructs a single-cell atlas of human putamen tissue from healthy controls, Parkinson's Disease, and Multiple System Atrophy to identify cell-type specific disease changes.

The paper identifies genome-wide significant epistasis interactions across 502 phenotypes using UK Biobank data and replicates some in Finngen consortium cohorts, revealing common variants' roles in complex diseases.

The paper analyzes single-cell RNA-seq data from COVID-19 patients to identify the lysosomal-immune axis as a factor associated with disease severity.

This paper computes a genome-wide polygenic risk score for Parkinson's Disease using 6.2 million variants and finds it strongly associates with increased disease risk and earlier onset.

The paper constructs a tissue- and organ-based subcellular-function atlas of obesity-related genes and pathways using publicly available datasets and integration methods.