Author

Cole Chute

University of Calgary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

Mashiat ZamaniD· 4 shared Timothy E. ShuttiD· 4 shared Armaan MohaniD· 2 shared Gerald PfefferiD· 2 shared R Luke WisemaniD· 2 shared Tyler SouleiD· 2 shared A Micheil Innes· 1 shared Adriana Zardini BuzattoiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Mashiat ZamanORCID

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4 papers

Recent·Most cited

Pathogenic Mitofusin 2 variants causing myopathy drive endosomal mtDNA release and inflammation

Mashiat Zaman, Joshua David, Ayshin Mehrabi, Cole Chute, Jingti Deng, Tyler Soule, Luke Wiseman, Costin N. Antonescu, Pina Colarusso, Gerald Pfeffer, Timothy E. Shutt

The paper identifies how pathogenic MFN2 variants cause mtDNA release into endosomes and mitochondrial-derived vesicles, triggering inflammation and myopathy, and suggests a therapeutic strategy using integrated stress response activation.

medRxiv · Sep 29, 2026 · PreprintGenetic & Genomic Medicine

Characterization of Ataxia-linked MFN2 Variants Reveals a Lipid Droplet/Mitochondrial Axis Driving Ferroptosis

Mashiat Zaman, Armaan Mohan, Cole Chute, Fernanda Sousa Monteiro, Adriana Zardini Buzatto, Timothy E. Shutt

The paper identifies ataxia-linked MFN2 variants that increase ferroptosis susceptibility by enhancing fatty acid import from lipid droplets to mitochondria, leading to lipid peroxidation and cell death.

medRxiv · Sep 21, 2026 · PreprintGenetic & Genomic Medicine

The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation

Mashiat Zaman, Govinda Sharma, Walaa Almutawa, Tyler Soule, Rasha Sabouny, Matthew Joel, Armaan Mohan, Cole Chute, Jeffrey T. Joseph, Gerald Pfeffer, Timothy E. Shutt

The paper identifies a novel MFN2 variant, Q367H, linked to mtDNA-mediated inflammation in a patient with distal myopathy, revealing a pathomechanism connecting MFN2 dysfunction to inflammatory signaling.

Life Science Alliance · Apr 2, 2025Peer-reviewedGenetic & Genomic Medicine

A novel variant in MFN2 linked to a lethal disorder of neonatal onset

Mashiat Zaman, Cole Chute, Julien L Marcadier, S Grewal, R Luke Wiseman, Amanda V Tyndall, Brenda L. McInnes, A Micheil Innes, Francois P Bernier, Timothy E. Shutt

The paper identifies a novel homozygous MFN2 variant R334K linked to a lethal neonatal disorder and shows it causes severe mitochondrial dysfunction, confirmed through functional studies and Drosophila modeling.

medRxiv · Sep 5, 2024 · PreprintGenetic & Genomic Medicine