Kinase independent function of PI3Kγ modulates calcium re-uptake by regulating phospholamban function
Maradumane L. Mohan, Connner P. Witherow, Robert S. Papay, Yu Sun, Kate T. Stenson, Sathyamangla V Naga Prasad
This study shows that PI3Kγ regulates calcium re-uptake in cardiomyocytes by modulating phospholamban phosphorylation through PP2A, independent of its kinase activity.
bioRxiv · May 11, 2021 · PreprintMolecular Biology