An Integrated Single-Cell Atlas Reveals Hepatic Stellate Cell Heterogeneity and Spatiotemporal Dynamics after Liver Injury
Jiongliang Wang, Jiawang Tao, Cuicui Xia, Miaoxiu Tang, Andrei-Florian Stoica, Shengxian Yuan, Yinxiong Li, Lin Guo, Xiangqian Kong, Jie Wang
This study constructs a cross-etiological HSC atlas to reveal HSC heterogeneity and spatiotemporal dynamics in liver injury, identifying a novel apoptosis-prone HSC subtype and a 531-gene fibrosis signature.
bioRxiv · Nov 25, 2025 · PreprintCell Biology