Author

D. A. Beard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

C. A. Figueroa· 2 shared E. Jones· 2 shared H. Gharahi· 2 shared A. Haidar· 1 shared B. E. Carlson· 1 shared D. Cameron· 1 shared D. G. Jakovljevic· 1 shared E. B. Randall· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersPhysiology

C. A. Figueroa

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Author profile →

5 papers

Recent·Most cited

Multiscale model of the physiological control of myocardial perfusion to delineate putative metabolic feedback mechanisms

H. Gharahi, C. A. Figueroa, J. D. Tune, D. A. Beard

The paper uses a multiscale model to evaluate metabolic feedback mechanisms in myocardial perfusion using porcine experimental data, identifying a likely mechanism linking MVO2 and flow.

bioRxiv · Aug 4, 2021Physiology

Phenotyping heart failure using model-based analysis and physiology-informed machine learning

E. Jones, E. B. Randall, S. L. Hummel, D. Cameron, D. A. Beard, B. E. Carlson

This paper uses cardiovascular system modeling and machine learning to phenotype heart failure subtypes, finding distinct mechanistic differences between HFrEF and HFpEF.

bioRxiv · Mar 3, 2021Physiology

A Constrained Mixture Theory Model to Study Autoregulation in the Coronary Circulation

H. Gharahi, D. A. Beard, C. A. Figueroa, S. Baek

This paper develops a structurally-motivated model of coronary autoregulation using constrained mixture theory to simulate hemodynamics and response to perfusion pressure changes in coronary trees.

bioRxiv · Sep 21, 2020 · PreprintPhysiology

Control of Cardiac Mitochondrial Fuel Selection by Calcium

E. Jones, S. M. Kandel, S. K. Dasika, N. Nourabadi, F. Van den Bergh, H. Sub Choi, A. Haidar, R. K. Dash, D. A. Beard

This study investigates how calcium ion concentration influences fuel selection in cardiac mitochondria, showing that it affects the ratio of carbohydrate to fatty acid utilization under varying ATP demand conditions.

bioRxiv · Aug 26, 2019 · PreprintBiochemistry

Cardiac Metabolic Limitations Contribute to Diminished Performance of the Heart in Aging

X. Gao, D. G. Jakovljevic, D. A. Beard

This study uses a population model to test how aging-related changes in myocardial metabolites affect cardiac performance and energy metabolism in adult women.

bioRxiv · Feb 25, 2019Physiology