D. Cameron

Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas

The paper identifies ATR as a target for combination EZH2 epigenetic therapy in SMARCB1-deficient sarcomas, showing that EZH2 inhibition promotes DNA damage via PGBD5, and that ATR inhibition enhances therapeutic responses.

Barriers to cascade screening in people at risk of Thoracic Aortic Disease: a mixed methods evaluation from the DECIDE-TAD initiative

This study identifies barriers to cascade screening for thoracic aortic disease using mixed methods, finding low uptake due to awareness, health literacy, and cost concerns.

Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy

This study identifies mechanisms of resistance to EZH2 inhibition in SMARCB1-deficient cancers and proposes combination therapies to overcome resistance.

A taxonomic revision of the genus Hydnora (Hydnoraceae)

This paper provides a taxonomic revision of the genus Hydnora, reinstating two species and describing a new one, with emphasis on osmophore characteristics and host range.

Childhood cancer mutagenesis caused by a domesticated DNA transposase

This study identifies PGBD5 as a primary mutator in medulloblastoma by showing it drives somatic DNA rearrangements in cerebellar progenitor cells.

Phenotyping heart failure using model-based analysis and physiology-informed machine learning

This paper uses cardiovascular system modeling and machine learning to phenotype heart failure subtypes, finding distinct mechanistic differences between HFrEF and HFpEF.

Unscrambling cancer genomes via integrated analysis of structural variation and copy number

This paper introduces LINX, a tool for analyzing structural variation and copy number alterations in cancer genomes, revealing novel insights into oncogenic fusions and inactivation events.

Rapid compensatory evolution can rescue low fitness symbioses following partner-switching

This study shows that partner-switching in the Paramecium-Chlorella symbiosis can lead to low fitness due to mismatched photoprotection traits, but compensatory evolution can rapidly restore fitness within 50 generations.