Author

D. A. Capdevila

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. P. Giedroc· 3 shared G. Gonzalez-Gutierrez· 2 shared Y. Zhang· 2 shared A. B. Dalia· 1 shared B. J. C. Walsh· 1 shared C. M. Dietrich· 1 shared C. M. P. Diez· 1 shared G. T. Antelo· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

D. P. Giedroc

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Author profile →

3 papers

Recent·Most cited

Increased intracellular persulfide levels attenuate HlyU-mediated hemolysin transcriptional activation in Vibrio cholerae

C. M. P. Diez, G. T. Antelo, T. N. Dalia, A. B. Dalia, D. P. Giedroc, D. A. Capdevila

This study shows that intracellular persulfide levels reduce HlyU-mediated hemolysin gene activation in V. cholerae by modulating reactive sulfur species sensing.

bioRxiv · Mar 13, 2023 · PreprintBiochemistry

Functional asymmetry and chemical reactivity of CsoR family persulfide sensors

J. Fakhoury, Y. Zhang, K. A. Edmonds, M. Bringas, J. Luebke, G. Gonzalez-Gutierrez, D. A. Capdevila, D. P. Giedroc

This study investigates the molecular basis of reactive sulfur species specificity in CstR proteins, revealing structural and chemical asymmetry in their reactivity.

Nucleic Acids Research · Nov 10, 2021Peer-reviewedBiochemistry

Structural determinants of persulfide-sensing specificity in a dithiol-based transcriptional regulator

D. A. Capdevila, B. J. C. Walsh, Y. Zhang, C. M. Dietrich, G. Gonzalez-Gutierrez, D. P. Giedroc

The paper identifies structural determinants of persulfide-sensing specificity in SqrR, showing that structural frustration of the disulfide form enhances tetrasulfide bridge formation and persulfide selectivity.

bioRxiv · Mar 22, 2020Biochemistry