Development of DuoMYC: a synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC
S. Pomplun, B. Ellenbroek, J. P. Kahler, D. Arella, C. Lin, W. Jespers
This paper develops DuoMYC, a synthetic miniprotein that inhibits MYC-driven transcription by binding to E-Box DNA with high affinity and stability.
bioRxiv · Mar 4, 2024Cancer Biology