Author

S. Pomplun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1

Frequent Co-Authors

B. L. Pentelute· 2 shared G. Zhang· 2 shared A. Akarca· 1 shared A. J. Quartararo· 1 shared A. Loas· 1 shared A. R. Loftis· 1 shared B. Ellenbroek· 1 shared C. Lin· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBioengineering

B. L. Pentelute

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Author profile →

4 papers

Recent·Most cited

Development of DuoMYC: a synthetic cell penetrant miniprotein that efficiently inhibits the oncogenic transcription factor MYC

S. Pomplun, B. Ellenbroek, J. P. Kahler, D. Arella, C. Lin, W. Jespers

This paper develops DuoMYC, a synthetic miniprotein that inhibits MYC-driven transcription by binding to E-Box DNA with high affinity and stability.

bioRxiv · Mar 4, 2024Cancer Biology

De Novo Discovery of High Affinity Peptide Binders for the SARS-CoV-2 Spike Protein

S. Pomplun, M. Jbara, A. J. Quartararo, G. Zhang, J. S. Brown, Y.-C. Lee, X. Ye, S. Hanna, B. L. Pentelute

This paper identifies high-affinity peptide binders for the SARS-CoV-2 spike protein using affinity selection-mass spectrometry, with nanomolar affinities and selectivity over human serum proteins.

bioRxiv · Sep 29, 2020Bioengineering

Investigation of ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD

G. Zhang, S. Pomplun, A. R. Loftis, X. Tan, A. Loas, B. L. Pentelute

This study investigates ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD using molecular dynamics simulations and peptide synthesis, finding that a 23-mer peptide fragment binds with micromolar affinity to insect-derived RBD but not HEK-expressed RBD.

bioRxiv · Mar 19, 2020 · PreprintBioengineering

Megakaryocytes, erythropoietic and granulopoietic cells express CAL2 antibody in myeloproliferative neoplasms carrying CALR gene mutations

H. Ali, I. Puccio, A. Akarca, R. Bob, S. Pomplun, W. K. Wong, R. Gupta, M. Sekhar, J. Lambert, H. Al-Masri, H. Stein, T. Marafioti

The paper validates the use of CAL2 antibody for detecting CALR mutations in MPNs through immunohistochemistry and confirms its specificity to mutated CALR in ET and MDS/MPN.

bioRxiv · Dec 22, 2019Pathology