Molecular Basis for G-protein-Coupled Receptor (GPCR) Activation and Biased Signalling at the Platelet Thrombin Receptor Proteinase Activated Receptor-4 (PAR4)
P. Thibeault, J. C. LeSarge, D. Arends, M. Fernandes, P. Chidiac, P. Stathopulos, L. G. Luyt, R. Ramachandran
This study identifies molecular determinants of PAR4 activation and biased signaling by analyzing peptide agonists and their interactions with the receptor.
bioRxiv · Sep 4, 2019Pharmacology & Toxicology