M. Fernandes

Discovery of free glycated amines and glycated urea as potential markers of diabetic nephropathy

The paper identifies glycated amines and glycated urea in diabetic patients' plasma as potential biomarkers for diabetic nephropathy.

MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

This paper identifies N-lobe MET mutations in HPRCC that require ligand stimulation for activation, unlike kinase domain mutations, and shows their sensitivity to MET inhibitors.

Development of a Plasmodium vivax biobank for functional ex vivo assays

This study develops an optimized cryopreservation method for Plasmodium vivax isolates and validates its effectiveness for long-term storage and functional assays.

A microfluidics-assisted methodology for label-free isolation of CTCs with downstream methylation analysis of cfDNA in lung cancer

This study develops a microfluidic method for label-free CTC isolation and cfDNA methylation analysis in lung cancer patients, showing improved diagnostic and prognostic potential through biomarker combinations.

Molecular Basis for G-protein-Coupled Receptor (GPCR) Activation and Biased Signalling at the Platelet Thrombin Receptor Proteinase Activated Receptor-4 (PAR4)

This study identifies molecular determinants of PAR4 activation and biased signaling by analyzing peptide agonists and their interactions with the receptor.