Physics-based inverse design of cholesterolattracting transmembrane helices reveals aparadoxical role of hydrophobic length
J. Methorst, N. Verwei, C. Hoffmann, P. Chodnicki, R. Sansevrino, H. Wang, N. van Hilten, D. Aschmann, A. Kros, L. Andreas, J. Czub, D. Milovanovic, H. J. Risselada
This paper uses evolutionary algorithms and molecular dynamics to identify optimal cholesterol-attracting transmembrane helices, revealing a paradoxical role of hydrophobic length.
bioRxiv · Jul 1, 2021Biophysics