C. Hoffmann

Condensates of synaptic vesicles and synapsin are molecular beacons for actin sequestering and polymerization

The paper investigates how synapsin-SV condensates organize presynaptic actin through LLPS, revealing their role in SV clustering and actin polymerization in lamprey and mammalian synapses.

Lipid packing and cholesterol content regulate membrane wetting and remodeling by biomolecular condensates.

This study shows that lipid packing and cholesterol content influence condensate-membrane interactions, with increased packing reducing condensate affinity.

Multi-faceted roles of β-arrestins in G protein-coupled receptors endocytosis

The paper challenges the conventional view of GPCR internalization by showing multiple pathways regulate receptor internalization, with specific findings on the GLP-1R's mechanism.

Key phosphorylation sites for robust β-arrestin2 binding at the mu-opioid receptor revisited

The paper investigates the role of GRK subfamilies in phosphorylation of the MOR C-tail and their impact on β-arrestin2 recruitment, showing GRK2/3 and GRK5/6 have distinct contributions.

Protein thiol alterations drive aberrant phase separation in aging

This study shows that aging-related changes in cysteine posttranslational modifications alter protein phase separation, leading to aggregation and neurodegeneration.

GRK specificity and beta gamma dependency determines a GPCR`s potential in biased agonism

This paper shows that GRK2/3's interaction with Gβγ is essential for β-arrestin2 recruitment to GPCRs, linking G protein activation to biased agonism potential.

Pharmacological characterization and radiolabeling ofVUF15485, a high-affinity small-molecule agonist for theatypical chemokine receptor ACKR3

This paper characterizes VUF15485, a high-affinity ACKR3 agonist, and reports its radiolabeling and binding properties.

A bacterial microbiome is dispensable for the induction of CD8 T cell exhaustion

This study shows that the microbiome is not required for T cell exhaustion in chronic LCMV infections, as germ-free mice exhibit similar exhaustion markers and gene expression patterns to specific pathogen-free mice.

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

This paper develops a bead-based immunoassay to quantify GPCR phosphorylation for ligand profiling and GRK inhibitor screening, demonstrating its utility with selective inhibitors.

Selectively expressed RNA molecules: a new dimension infunctionalized cell targeting

The paper develops selectively expressed RNA molecules (seRNAs) that target specific cell types and enable functionalization for therapy, showing efficacy in reducing glioblastoma tumors in mice.

GM-CSF-activated human dendritic cells promote type1 T follicular helper cells (Tfh1) polarization in a CD40-dependent manner

This study shows GM-CSF-activated human dendritic cells drive Tfh1 differentiation via CD40-dependent mechanisms, with implications for infections like tuberculosis and COVID-19.

A nano-liquid hub integrating growth and immune-evasion signaling to promote cell survival

The paper identifies GEM, a nano-liquid hub that integrates growth and immune-evasion signaling to enhance cell survival in mice.

Bacteriocinogenic lactic acid bacteria in the traditional cereal-based beverage Boza: a genomic and functional approach

This study identifies bacteriocinogenic Lactic Acid Bacteria in Boza using genomic and functional analyses, showing their antimicrobial activity against foodborne pathogens.

Lung epithelial CYP1 activity regulates aryl hydrocarbon receptor dependent allergic airway inflammation

This study investigates the role of CYP1 family members and AhR in lung epithelial regulation of allergic airway inflammation, finding that CYP1B1 deficiency exacerbates inflammation.

High Level of Interaction between Phages and Bacteria in an Artisanal Raw Milk Cheese Microbial Community

The paper analyzes viral and bacterial metagenomes in Canastra cheese to identify phage-bacteria interactions and their potential impact on cheese fermentation and sensory properties.

Physics-based inverse design of cholesterolattracting transmembrane helices reveals aparadoxical role of hydrophobic length

This paper uses evolutionary algorithms and molecular dynamics to identify optimal cholesterol-attracting transmembrane helices, revealing a paradoxical role of hydrophobic length.

GRK2/3/5/6 knockout: The impact of individual GRKs on arrestin-binding and GPCR regulation

This study investigates the role of individual GRKs in GPCR regulation and β-arrestin interactions using GRK knockout cells and identifies distinct GRK-mediated mechanisms.

MMP2 As An Independent Prognostic Stratifier In Oral Cavity Cancers

The paper identifies MMP2 as an independent prognostic biomarker for oral cavity cancers, associated with poor disease-specific survival.

PDL1 AND ICOSL DISCRIMINATE HUMAN SECRETORY AND HELPER DENDRITIC CELLS

The paper identifies two functional states of human activated dendritic cells, secretory DC and helper DC, distinguished by PDL1 and ICOSL expression and their distinct cytokine profiles and T cell stimulation capacities.