Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice
F. I. Rome, G. L. Shobert, W. C. Voigt, D. B. Stagg, P. Puchalska, S. C. Burgess, P. A. Crawford, C. C. Hughey
This study shows that loss of hepatic PEPCK1 impairs acute exercise glucose regulation but improves liver lipid reduction and muscle mitochondrial adaptations with exercise training in mice.
bioRxiv · Sep 22, 2022Physiology