Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution.
M. E. Monberg, H. Geiger, R. Sharma, J. J. Lee, A. Semaan, V. Bernard, D. B. Swartzlander, B. M. Stephens, K. Chen, M. H. Katz, N. Robine, P. A. Guerrero, A. Maitra
This study reveals high intratumoral heterogeneity in pancreatic cancer cell lines and highlights issues with reproducibility and validity of preclinical models.
bioRxiv · Apr 13, 2021Cancer Biology