A. Maitra

Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas

This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.

TGFb-ANGPT2-Tie2 axis in cancer-associated fibroblasts reprograms oral cancer cells to embryonic-like cell state with predictive significance of poor prognosis

The paper identifies the TGFβ-ANGPT2-Tie2 axis in cancer-associated fibroblasts that reprograms oral cancer cells to an embryonic-like state, linked to poor prognosis.

A Rigorous Multi-Laboratory Study of Known PDAC Biomarkers Identifies Increased Sensitivity and Specificity Over CA19-9 Alone

This study evaluates combinations of PDAC biomarkers across multiple labs, finding improved sensitivity and specificity for early-stage detection compared to CA19-9 alone.

The impact of physiological state and environmental stress on bacterial load estimation methodologies for Mycobacterium tuberculosis

This study evaluates how bacterial growth phase and drug exposure affect bacterial load estimation methods for Mycobacterium tuberculosis.

Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia

This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.

Prognostic relevance of correlated co-expression of coding and noncoding RNAs in cervical cancers

The paper identifies prognostically relevant co-expression patterns between coding and noncoding RNAs in HPV16-positive cervical cancers and links them to patient survival.

Aging and freezing of active nematic dynamics of cancer-associated fibroblasts by fibronectin matrix remodeling

This study investigates how fibronectin matrix remodeling by cancer-associated fibroblasts (CAFs) influences their nematic dynamics, revealing aging and freezing of defect motion in the ECM.

Integrated spatial transcriptomics and lipidomics of precursor lesions of pancreatic cancer identifies enrichment of long chain sulfatide biosynthesis as an early metabolic alteration

Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of The Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential

This study identifies NKX6-2 as a driver of gastric differentiation in IPMNs, linking its expression to indolent biological potential and progression.

Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner

This study shows that MRTX1133, a KrasG12D inhibitor, reduces early pancreatic lesions and, when combined with immunotherapy, regresses advanced PDAC by enhancing CD8+ T cell activity.

Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-specific Transcriptome and Molecular Subtype

This study uses deep learning on plasma extracellular vesicle RNA to predict cancer subtypes, monitor treatment effects, and identify gene fusions and neoepitopes without tissue sampling.

Testing a theoretical framework for the environment-species abundance paradigm: a new approach to the Abundant Centre Hypothesis

The paper tests the Abundant Centre Hypothesis by analyzing bird abundance data across an elevational transect, finding symmetric community profiles and elevation-dependent species asymmetry.

Programmable in vivo CRISPR activation elucidates the oncogenic and immunosuppressive role of MYC in lung adenocarcinoma

This study uses CRISPR activation to show MYC promotes lung cancer growth and creates an immunosuppressive tumor environment, suggesting combined MYC/immune therapies could benefit patients.

Oncogenic KRAS Requires Complete Loss of BAP1 Function for Development of Murine Intrahepatic Cholangiocarcinoma

This study develops a mouse model showing that complete loss of BAP1 function is required for KRAS-driven intrahepatic cholangiocarcinoma.

Altered DNA methylation in ion transport and immune signalling genes is associated with severity in Pancreatic Ductal Adenocarcinoma

This study identifies DNA methylation changes in PDAC associated with disease severity and finds concordance with TCGA-PAAD and GTEx datasets.

Loss of Rnf43 accelerates Kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma

This study shows that loss of Rnf43 accelerates Kras-driven pancreatic cancer and alters the tumor immune microenvironment by increasing lymphocytes and immune checkpoint expression.

Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment

This study shows that deleting HIF2 in cancer-associated fibroblasts reduces pancreatic tumor growth and immunosuppression, suggesting HIF2 as a therapeutic target.

Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution.

This study reveals high intratumoral heterogeneity in pancreatic cancer cell lines and highlights issues with reproducibility and validity of preclinical models.

Diversity Across the Pancreatic Ductal Adenocarcinoma Disease Spectrum Revealed by Network-Anchored Functional Genomics

This study introduces CoDEX, a framework that links gene-cluster patterns with genetic vulnerabilities in PDAC, revealing subtype-specific dependencies and their impact on tumor phenotypes.

Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsies

This study uses scRNA-seq on pancreatic cancer biopsies to characterize tumor-stromal heterogeneity and ligand-receptor interactions, showing its utility over patient-derived organoids for precision oncology.

Fatal toxicity of chloroquine or hydroxychloroquine with metformin in mice

The paper reports that chloroquine or hydroxychloroquine combined with metformin causes lethal toxicity in mice, highlighting potential clinical risks.

Paradoxical role of AT-rich interactive domain 1A in restraining pancreatic carcinogenesis

This study investigates the role of Arid1a in pancreatic carcinogenesis using mouse models and cell lines, finding that its loss impairs tumor growth and DNA repair but allows for later aggressive cancer development.

YAP1 Oncogene is a Context-specific Driver for Pancreatic Ductal Adenocarcinoma

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

This study uses single-cell RNA sequencing to analyze cellular heterogeneity in mouse pancreatic ductal adenocarcinoma progression, identifying epithelial-to-mesenchymal transition, inflammatory macrophages, and fibroblast subtypes.

A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9 mediated somatic recombination

This paper develops a CRISPR-Cas9-based pipeline to generate pancreatic cancer mouse models with complex genotypes using AAV-delivered sgRNAs in adult mice.

Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

This study uses single-cell RNA sequencing to analyze transcriptomic changes in pancreatic cancer precursors, revealing epithelial and microenvironmental heterogeneity during progression to cancer.