R. Sharma

HOXA10 is a Temporal Switch in Controlling Decidual Inflammation and Its Dysregulation is Associated with Early Pregnancy Loss

This study identifies HOXA10 as a temporal switch regulating decidual inflammation, showing its dysregulation contributes to early pregnancy loss in mice and humans.

Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications

The paper models how CpG island density and epigenetic modifications affect DNA nucleosome wrapping energy and probability.

BLOC1S1 control of vacuolar organelle fidelity modulates TH2 cell immunity and allergy susceptibility.

This study shows that BLOC1S1 depletion disrupts mitochondrial integrity, leading to TH2 cell immunity and allergy susceptibility via STING-NF-κB signaling.

Quantifying the varying harvest of fermentation products from the human gut microbiota

The paper quantifies the metabolic flux of fermentation products from the gut microbiota, showing it varies with diet but not microbiota composition.

Local adaptation to mercury contamination by nitrogen-fixing rhizobia is driven by horizontal gene transfer, copy number, and enhanced gene expression

This study identifies that horizontal gene transfer, copy number, and enhanced expression of the Mer operon confer mercury tolerance in rhizobia, with implications for plant-metal interactions.

Preclinical Characterization of the Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine

The monovalent Omicron XBB.1.5-adapted BNT162b2 mRNA vaccine elicits stronger neutralizing antibody responses against XBB.1.5 and related sublineages than the bivalent Wild Type + Omicron BA.4/5 vaccine.

A tomato ethylene-insensitive mutant displays altered growth and higher β-carotene levels in fruit

Coordination Between Cytoplasmic and Envelope Densities Shapes Cellular Geometry in Escherichia coli

This study develops and validates a biophysical model showing that constant ratios of cytoplasmic and membrane protein densities regulate Escherichia coli cell geometry through proteome partitioning and ribosome content.

The incidence of movement disorders increases with age and contrasts with subtle and limited neuroimaging abnormalities in argininosuccinic aciduria.

This study investigates movement disorders in argininosuccinic aciduria (ASA), finding they increase with age and show specific neuroimaging abnormalities not seen in mouse models.

Investigating the genetic control of plant development under speed breeding conditions

This study identifies genetic loci controlling plant development under speed breeding conditions and finds that allelic variation at ELF3 influences flowering and maturity plasticity.

Evaluation of morpho-physiological and yield-associated traits of rice (Oryza sativa L.) landraces combined with marker-assisted selection under high temperature stress and elevated atmospheric CO2 levels

This study evaluates NEI rice landraces under high temperature and elevated CO2 stress, identifying two landraces with better performance and genetic variation for breeding stress-tolerant rice.

Progressive plasticity during colorectal cancer metastasis

This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD

This study identifies the AKT2/SIRT5/TFEB pathway as a therapeutic target for atrophic AMD by showing its role in lysosomal dysfunction and drusen formation in RPE cells.

Establishing Ac/Ds Starter Lines for Large-Scale Transposon-Tagged Mutagenesis in Tomato

The paper develops two tomato starter lines with maize transposon elements and transposase to enable large-scale transposon mutagenesis for gene functional validation.

Human hnRNPA1 reorganizes telomere-bound Replication Protein A

The paper shows hnRNPA1 remodels RPA bound to telomeric ssDNA, forming a ternary complex regulated by TERRA.

A riboswitch-controlled manganese exporter (Alx) tunes intracellular Mn2+ concentration in E. coli at alkaline pH

This study shows that the Alx protein, regulated by a riboswitch, exports excess Mn2+ in E. coli under alkaline conditions to maintain intracellular Mn2+ homeostasis.

Introgression of a dominant phototropin1 mutant superenhances carotenoids and boosts flavor-related volatiles in genome-edited tomato RIN mutants

This study introduces a tomato cultivar with extended shelf life, improved taste, and flavor by combining genome-edited ripening mutants with a phototropin1 mutant.

Proteomic Investigation of Neural Stem Cell to Oligodendrocyte Precursor Cell Differentiation Reveals Phosphorylation-Dependent Dclk1 Processing

The paper uses proteomics to study NSC to OPC differentiation, identifying Dclk1 phosphorylation-regulated isoform switching as a key process.

An improved mouse model of sepsis based on intraperitoneal injections of the enriched culture of cecum slurry

The paper introduces an improved sepsis model in mice using intraperitoneal injection of enriched cecal slurry cultures, enabling reproducible and ethical sepsis induction.

Designer grass pea for transgene-free minimal neurotoxin-containing seeds with CRISPR-Cas9

This study uses CRISPR-Cas9 to create grass pea plants with minimal neurotoxin {beta}-ODAP in seeds, achieving 99% reduction without transgenes.

Flexible IrOx Neural Electrode for Mouse Vagus Nerve Stimulation

This paper develops and evaluates a flexible IrOx electrode for mouse vagus nerve stimulation, showing it remains functional under high stimulation and induces reliable physiological responses.

In-vitro activity of Cefiderocol against clinical isolates of meropenem-resistant Klebsiella pneumoniae from India.

This study compares the in-vitro activity of cefiderocol with other antibiotics against meropenem-resistant Klebsiella pneumoniae isolates from India.

Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression

The paper investigates how 9p21.3 deletions in cancer disable both cell intrinsic and extrinsic tumor suppression by co-deleting CDKN2A/B and type I interferons, leading to immune evasion and metastasis.

Deep-Worm-Tracker: Deep Learning Methods for Accurate Detection and Tracking for Behavioral Studies in C. elegans

Deep-Worm-Tracker uses deep learning to accurately detect and track C. elegans worms in videos, achieving high precision and real-time performance.

Reduced γ-glutamyl hydrolase activity likely contributes to high folate levels in Periyakulam-1 tomato

The paper identifies reduced γ-glutamyl hydrolase activity in PKM-1 tomato as a factor contributing to higher folate levels compared to AV.

Oxytocin receptor is not required for social attachment in prairie voles

This study shows that oxytocin receptor signaling is not required for social attachment, parturition, or parental behavior in prairie voles.

C-terminal disulfide bond in SUN2 regulate dynamic remodeling of LINC complexesat the nuclear envelope

This study identifies a C-terminal disulfide bond in SUN2 that regulates LINC complex dynamics and function through redox state changes.

An auto-inhibited state of protein kinase G and implications for selective activation

This study presents crystal structures of PKG Iβ in auto-inhibited and activated states, revealing the mechanism of cGMP-mediated activation and isoform-specific regulation.

Whole-Genome Profiling of Ethyl Methanesulfonate Mutagenesis in Tomato

This study sequenced mutagenized tomato lines to identify mutations, revealing high mutation density and novel insights into EMS mutagenesis patterns and their impact on metabolic pathways.

CARP2 regulates the Golgi dynamics upon EGF stimulation

This study shows CARP2 regulates Golgi dispersal upon EGF stimulation by ubiquitinating Golgin45.