ImmunologybioRxiv
N-terminal degradation activates the Nlrp1b inflammasome
D. Bachovchin, A. J. Chui, M. Okondo…·B. Vittimberga
The paper identifies N-terminal degradation as the mechanism for Nlrp1b inflammasome activation, leading to caspase-1 activation and pyroptotic cell death.
DOI 10.1126/science.aau1208