Author

A. J. Chui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

A. R. Griswold· 2 shared D. A. Bachovchin· 2 shared D. P. Ball· 2 shared E. L. Orth-He· 2 shared H.-C. Huang· 2 shared Q. Wang· 2 shared A. Bhattacharjee· 1 shared A. Griswold· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersImmunology

A. R. Griswold

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A ubiquitin-independent proteasome pathway controls the CARD8 inflammasome

J. C. Hsiao, A. R. Neugroschl, A. J. Chui, C. Y. Taabazuing, A. R. Griswold, Q. Wang, H.-C. Huang, E. L. Orth-He, D. P. Ball, G. Hiotis, D. A. Bachovchin

This study identifies a ubiquitin-independent proteasome pathway that degrades the CARD8 N-terminal fragment, releasing the inflammatory C-terminal fragment and activating the inflammasome.

bioRxiv · Mar 22, 2022 · PreprintImmunology

Cytosolic peptide accumulation activates the NLRP1 and CARD8 inflammasomes

E. L. Orth-He, H.-C. Huang, S. D. Rao, Q. Wang, Q. Chen, C. M. O'Mara, A. J. Chui, M. Saoi, A. R. Griswold, A. Bhattacharjee, D. P. Ball, J. R. Cross, D. A. Bachovchin

This study identifies cytosolic peptide accumulation as a danger signal that activates NLRP1 and CARD8 inflammasomes by promoting NT degradation and disrupting DPP9-mediated sequestration of CT fragments.

bioRxiv · Mar 22, 2022 · PreprintImmunology

N-terminal degradation activates the Nlrp1b inflammasome

D. Bachovchin, A. J. Chui, M. Okondo, S. Rao, K. Gai, A. Griswold, B. Vittimberga

The paper identifies N-terminal degradation as the mechanism for Nlrp1b inflammasome activation, leading to caspase-1 activation and pyroptotic cell death.

bioRxiv · May 9, 2018Immunology