Loss of charge at solvent exposed Lys residues does not induce the aggregation of superoxide dismutase 1
K. Crosby, A. M. Crown, B. L. Roberts, H. Brown, J. I. Ayers, D. Borchelt
This study shows that losing positive charge at surface lysine residues in SOD1 does not cause misfolding or aggregation, suggesting these mutations are not disease drivers.
bioRxiv · Apr 14, 2018Biochemistry