Accumulation of prelamin A drives inflammation in the heart with implications for treatment of inherited and acquired cardiomyopathies
D. Brayson, A. Frustaci, R. Verardo, C. Chimenti, M. A. Russo, R. Hayward, S. M. Ahmad, G. Vizcay-Barrena, A. Protti, P. S. Zammit, C. G. dos Remedios, E. Ehler, A. M. Shah, C. M. Shanahan
This study shows prelamin A accumulation drives inflammation in both inherited and acquired cardiomyopathies, suggesting potential treatment strategies targeting inflammation.
bioRxiv · Nov 28, 2018Pathology