Pharmacology & ToxicologybioRxiv
Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.
L. Hong, d. C. Braden, Y. Zhao…·C. A. Carola
This paper identifies nitroalkenes that inhibit RAD51-mediated homologous recombination, enhancing DNA damage in triple-negative breast cancer cells and showing potential as anticancer agents.
DOI 10.1016/j.redox.2023.102856