A. Casey

Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.

This paper identifies nitroalkenes that inhibit RAD51-mediated homologous recombination, enhancing DNA damage in triple-negative breast cancer cells and showing potential as anticancer agents.

Transcriptome changes in chlorsulfuron-treated plants are caused by acetolactate synthase inhibition and not induction of a herbicide detoxification system in Marchantia polymorpha

This study shows that chlorsulfuron-induced transcriptome changes in Marchantia polymorpha are due to acetolactate synthase inhibition, not a detoxification response.

Genes encoding cytochrome P450 monooxygenases and glutathione S-transferases associated with herbicide resistance evolved before the origin of land plants

The paper identifies that CYP and GST genes associated with herbicide resistance evolved in the common ancestor of land plants and streptophyte algae, with gene duplications increasing their numbers in land plants.

Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response

This study shows Nrf2 regulates macrophage metabolism, redox balance, and inflammatory responses, with 4-OI modulating these effects through Nrf2.

Structures of an intact yeast V-ATPase alone and in complex with bacterial effector VopQ

This study reports cryo-EM structures of the intact yeast V-ATPase and its complex with the bacterial effector VopQ, revealing interactions and catalytic conformations.

Cold Atmospheric Plasma induces silver nanoparticle uptake, oxidative dissolution and enhanced cytotoxicity in Glioblastoma multiforme cells

This study shows that combining cold atmospheric plasma with silver nanoparticles significantly increases cytotoxicity in glioblastoma cells through enhanced nanoparticle uptake and oxidative stress.

Loss of microbial diversity and pathogen domination of the gut microbiota in critically ill patients

This study examines changes in gut microbiota diversity and pathogen presence in ICU patients, finding reduced diversity and pathogen domination linked to antimicrobial use.

A high-throughput whole cell screen to identify inhibitors of Mycobacterium tuberculosis

The paper develops a high-throughput whole-cell screen to identify inhibitors of Mycobacterium tuberculosis growth, identifying three chemical classes with ≥90% growth inhibition.