Y. Zhao

NINJ1 mediates hepatic ischemia-reperfusion injury

This study identifies NINJ1 as a mediator of hepatic ischemia-reperfusion injury, showing its role in cell death and inflammation, and suggests it as a therapeutic target.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Linear-regression-based algorithms can succeed at identifying microbial functional groups despite the nonlinearity of ecological function

The paper evaluates regression-based methods for identifying microbial functional groups using synthetic data, finding that simpler linear methods can outperform complex ones.

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

Molecular interplay between HURP and Kif18A in mitotic spindle regulation

This study investigates how HURP regulates Kif18A motility and microtubule dynamics during mitosis using single-molecule imaging and Cryo-EM.

Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly

This paper introduces a soft-lithography-based acoustic bioassembly technique to create complex multicellular structures with functional liver tissue mimic capabilities.

Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar

This study identifies rare variants under positive selection in wild boar linked to cold adaptation, showing convergent molecular evolution with humans.

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

This study shows that Piezo1 in intestinal L cells mechanically regulates GLP-1 production, affecting glucose tolerance and diabetes.

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers

This paper identifies transcription-replication conflict as a vulnerability in ecDNA-containing cancers and demonstrates that CHK1 inhibition selectively kills these tumors.

3D live imaging and phenotyping of the subcellular cytotoxicity in cancer immunotherapy using event-triggered Bessel oblique plane microscopy

This study uses EBOPM to analyze subcellular events in CAR-T cells during immunotherapy, identifying key parameters correlated with cytotoxic function.

The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice

This study investigates the evolutionary history of cultivated rice and identifies genomic signatures of heterosis in super-hybrid rice varieties.

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.

Biomimetic fractal topography enhances podocyte maturation in vitro

This study shows that biomimetic fractal topography improves podocyte maturation in vitro by enhancing marker expression, cell polarity, and ECM remodeling via YAP signaling.

PARP14 inhibits the inflammatory response of macrophages through the NF-κB pathway

This study shows PARP14 inhibits macrophage inflammatory responses by suppressing the NF-κB pathway, as demonstrated through genetic knockout and pharmacological inhibition.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing

This study enhances CAR-NK cell functionality using non-viral base editing and transposon integration, showing improved therapeutic potential in Burkitt's lymphoma models.

Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide

This study identifies 16216 cisplatin-damaged genes in human lung cancer cells and shows cisplatin disrupts protein phosphorylation signalling by targeting 85% of protein kinase and 81% of phosphatase genes.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

The GPI sidechain of Toxoplasma gondii prevents parasite pathogenesis

This paper identifies and characterizes glycosyltransferases in Toxoplasma gondii that modify GPI sidechains, showing that their absence increases parasite virulence.

Nasal commensals reduce Staphylococcus aureus proliferation by restricting siderophore availability

The paper shows nasal commensals reduce S. aureus growth by consuming its siderophores, revealing inter-species competition and potential for probiotic strategies.

Nodulation Trio in Medicago truncatula: Unveiling the Overlapping Roles of MtLYK2, MtLYK3, and MtLYK2bis

This study investigates the roles of MtLYK2, MtLYK3, and MtLYK2bis in Medicago truncatula nodulation using CRISPR/Cas mutants, finding redundant functions and suggesting a one-receptor model with multiple specificities.

CAMKV Kinase Signaling Is a Novel Therapeutic Avenue with Prognostic Relevance in Neuroblastoma

This study identifies CAMKV kinase signaling as a critical driver of neuroblastoma growth and shows it as a potential therapeutic target and prognostic marker.

In vivo validation of an in situ calibration bead as a reference for backscatter coefficient calculation

The paper validates an in situ titanium bead as a calibration reference for improving backscatter coefficient estimation in quantitative ultrasound by reducing bias from tissue attenuation and transmission loss.

Single-Cell Transcriptomic Profiling Unveils Critical Metabolic Alterations and Signatures in Progression of Atherosclerosis

This study uses single-cell RNA sequencing to identify metabolic changes and gene signatures in atherosclerosis progression, revealing altered metabolic pathways and cell-cell interactions.

Granulosa cell-layer stiffening prevents the granulosa cells from escaping the post-ovulatory follicle

The paper shows that granulosa cell-layer stiffening, driven by focal adhesion assembly and LH signaling, prevents granulosa cells from escaping the post-ovulatory follicle.

A neutral process of genome reduction in marine bacterioplankton

The paper investigates genome reduction in marine bacterioplankton, finding that neutral processes like genetic drift, not streamlining selection, drive genome size reduction in the Roseobacter group.

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α

Cost-benefit analysis of cryogenic electron tomography subtomogram averaging of chaperonin MmCpn at near atomic resolution.

This study analyzes the factors affecting resolution in cryoET-STA for MmCpn, evaluating the cost-benefit of achieving high-resolution structures.

The integrated stress response/eIF2α pathway controls cytokine production in tissue-resident memory CD4+ T cells

This study shows that the ISR/eIF2α pathway regulates cytokine mRNA translation in Trm cells, limiting their activity in homeostasis but enabling rapid response during inflammation or autoimmunity.

YamOmics: A comprehensive data resource on yam multi-omics

YamOmics compiles and organizes multi-omics data from 41 yam species, providing genomic, transcriptomic, and plastomic data along with variant and expression information for yam research and breeding.