Author

D. C. James

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. J. Nicklin· 2 shared A. Brown· 1 shared A. J. Brown· 1 shared A. O. Johnson· 1 shared J. Grinham· 1 shared J. M. Scarrott· 1 shared J. Price· 1 shared K. L. Tee· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

M. J. Nicklin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Protein-specific signal peptides for mammalian vector engineering

P. O'Neill, R. K. Mistry, A. J. Brown, D. C. James

This paper develops a toolkit of signal peptides for mammalian cell expression, validated by increasing protein titers by 1.8x using machine learning and in silico/in vitro testing.

bioRxiv · Mar 14, 2023Bioengineering

ACE2-independent interaction of SARS-CoV-2 spike protein to human epithelial cells can be inhibited by unfractionated heparin

L. J. Partridge, L. Urwin, M. J. Nicklin, D. C. James, L. R. Green, P. N. Monk

This paper shows that SARS-CoV-2 spike protein can interact with human cells without ACE2 and that unfractionated heparin inhibits this interaction.

Cells · Jun 7, 2021Peer-reviewedMicrobiology

Purification of recombinant SARS-CoV-2 spike, its receptor binding domain, and CR3022 mAb for serological assay

K. L. Tee, P. J. Jackson, J. M. Scarrott, S. R. Jaffe, A. O. Johnson, Y. Johari, T. H. Pohle, T. Mozzanino, J. Price, J. Grinham, A. Brown, M. J. Nicklin, D. C. James, M. J. Dickman, T. S. Wong

The paper describes methods for purifying SARS-CoV-2 spike protein, its receptor binding domain, and CR3022 mAb, and validates their use in serological assays.

bioRxiv · Jul 31, 2020 · PreprintBiochemistry