A. Brown

Collateral fitness effects of mutation are not commonly caused by protein misfolding

The paper tests if protein misfolding causes collateral fitness effects from mutations and finds it is not common, but misfolding does drive primary fitness costs when function is essential.

Reproductive output of old polygynous males is limited by seminal fluid, not sperm number

This study shows that reproductive decline in old polygynous males is due to seminal fluid limitations, not sperm number, using Drosophila melanogaster.

Chemical mate choice copying in Drosophila melanogaster

This study demonstrates chemical mate choice copying in Drosophila melanogaster, showing females preferentially select male genotypes previously chosen by mated females.

Expanding the RNA polymerase biocatalyst solution space for mRNA manufacture

This paper expands the RNA polymerase biocatalyst solution space for mRNA manufacture by identifying and validating eight novel RNAPs and their promoters through a high-throughput screening platform.

Stress contingent changes in Hog1 pathway architecture and regulation in Candida albicans

This study identifies stress-dependent changes in Hog1 pathway regulation in C. albicans, revealing Ssk1's role as a scaffold and its impact on Hog1 phosphorylation under different stress conditions.

Single-cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosis

This study uses single-cell multiomic analysis to identify transcriptional circuits driving non-ischemic cardiac fibrosis in mouse and human hearts, showing reversibility of fibrosis-related changes.

Molecular response to multiple trace-element contamination of the European sardine

This study investigates the molecular response of European sardines to trace-element contamination, finding upregulated stress and immune pathways and potential biomarkers for monitoring sardine health.

ROS responsive Aux/IAA multimerization modulates auxin responses

The paper shows ROS-induced IAA3/SHY2 multimerization regulates auxin responses during xerobranching and lateral root emergence in plants.

Genome-wide patterns of non-coding sequence variation in the major fungal pathogen Aspergillus fumigatus

This study identifies greater sequence variation in non-coding regions of A. fumigatus genes compared to protein-coding regions, suggesting a role in phenotypic differences between strains.

Early Neolithic forest farming at Seven Springs, Martlesham, Suffolk inferred from sedaDNA and pollen

This study uses sedaDNA and pollen analysis to show Early Neolithic agro-pastoralists used wetland springs for pastoral and ritual activities in Suffolk, UK.

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

This study develops a trivalent RBD nanoparticle vaccine that protects mice against both merbecovirus and sarbecovirus challenges, including SARS-CoV, MERS-CoV, and SARS-CoV-2.

Evolution of sex differences in cooperation: the role of trade-offs with dispersal

This study tests hypotheses about sex differences in cooperation by analyzing dispersal patterns in white-browed sparrow weavers, finding support for the Dispersal trade-off hypothesis over the Philopatry hypothesis.

Consideration of a liquid mutation accumulation experiment to measure mutation rates by successive serial dilution.

The paper proposes a liquid-phase mutation-accumulation experiment to measure mutation rates and spectra, demonstrating it can replicate results from plate-based experiments and detect a modified mutation spectrum.

The glucocorticoid receptor is a critical regulator of muscle satellite cell quiescence.

This study shows that the glucocorticoid receptor regulates muscle satellite cell quiescence, with its loss leading to increased activation and proliferation.

Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential

This study evaluates the antiviral efficacy of GS-5245 against multiple SARS-CoV-2 variants and other coronaviruses, showing broad in vitro activity and protective effects in animal models.

Identification of proteins that bind extracellular microRNAs secreted by the parasitic nematode Trichinella spiralis

The paper identifies two RNA-binding proteins secreted by Trichinella spiralis that bind miRNAs, suggesting a mechanism for their extracellular stability.

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

The paper investigates non-canonical ORF translation in medulloblastoma, identifying ASNSD1-uORF as critical for cell survival through interactions with the prefoldin-like chaperone complex.

Synthesis and validation of click-modified of NOD1/2 agonists

This study synthesizes and validates click-modified muropeptides as tools to study NOD1/2 innate immune sensing mechanisms.

Vascular Smooth Muscle Cell Mechanotransduction Through Serum and Glucocorticoid Inducible Kinase-1 Promotes Interleukin-6 Production and Macrophage Accumulation in Murine Hypertension

This study shows that SGK-1 in vascular smooth muscle cells promotes IL-6 and macrophage accumulation in hypertension via mechanotransduction and AngII signaling.

Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse

This study identifies RRM2 and RRM2B as key players in hepatoblastoma progression and drug response, showing their dynamic switching and impact on relapse.

Spatiotemporal Dynamics of Vcam1 Regulates Cholangiocarcinoma Mass Expansion and Tumor Dissemination under Growth-suppressive Peritumoral Myofibroblasts

This study shows that Vcam1 expression in cholangiocarcinoma cells is regulated by peritumoral myofibroblasts, promoting tumor dissemination while suppressing growth.

Mutual antagonism between glucocorticoid and canonical Wnt signaling pathways in B-cell acute lymphoblastic leukemia

The paper identifies mutual antagonism between glucocorticoid and canonical Wnt signaling pathways in B-cell acute lymphoblastic leukemia, linking TLE1 cis-regulatory disruptions to GC resistance.

30x30 biodiversity gains rely on national coordination

The paper evaluates 30x30 conservation scenarios in Canada, finding national coordination protects more biodiversity than regional approaches.

High Density Domain-Focused CRISPR Screens Reveal Novel Epigenetic Regulators of HOX/MEIS Activation in Acute Myeloid Leukemia

The paper identifies SGF29 as a novel chromatin regulator of MEIS1 and AML oncogenes, showing its role in leukemogenesis and potential as a drug target.

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

The paper identifies ancestry-related biases in CRISPR experiments caused by germline variants, showing disproportionate effects in cell models from recent African descent.

Context-induced renewal of passive but not active coping behaviours in the shock-probe defensive burying task

This study investigates whether passive and active coping behaviors show renewal after extinction in a shock-probe defensive burying task, finding renewal in passive behaviors but not active ones.

Molecular Basis for Interferon-mediated Pathogen Restriction in Human Cells

This study identifies RNF213 as essential for IFN-gamma-mediated restriction of intracellular pathogens like Toxoplasma gondii and Mycobacterium tuberculosis through ubiquitination, independent of autophagy.

Methotrexate inhibition of muropeptide transporter SLC46A2 controls psoriatic skin inflammation

The paper shows that SLC46A2 transports DAP-muropeptides to activate NOD1 in keratinocytes, and methotrexate inhibits this transport, reducing psoriatic inflammation.

ESCRT-dependent STING degradation curtails steady-state and cGAMP-induced signaling

The paper identifies an ESCRT complex that degrades STING to suppress its signaling, showing its role in maintaining immune homeostasis.

Cancer-associated SMARCAL1 loss-of-function mutations promote alternative lengthening of telomeres and tumorigenesis in telomerase-negative glioblastoma cells

This study shows SMARCAL1 loss-of-function mutations enable ALT in telomerase-negative glioblastoma cells, promoting tumorigenesis and telomere maintenance.