Hemin-driven chromatin remodelling by atherosclerotic risk gene SMARCA4 switches human blood-derived macrophages from leukocyte disposal to erythrocyte disposal
L. Cave, K. M. Lodge, D. Chiappo, S. Sinha, F. Chugtai, A. Tsao, J. C. Mason, D. O. J. Haskard, S. E. Humphries, J. J. Boyle
This study shows SMARCA4 drives hemin-induced chromatin changes in macrophages, switching their phagocytic target from leukocytes to erythrocytes, contributing to atherosclerosis.
bioRxiv · May 1, 2023 · PreprintPathology