PathologybioRxivPreprint
Hemin-driven chromatin remodelling by atherosclerotic risk gene SMARCA4 switches human blood-derived macrophages from leukocyte disposal to erythrocyte disposal
L. Cave, K. M. Lodge, D. Chiappo…·J. J. Boyle
This study shows SMARCA4 drives hemin-induced chromatin changes in macrophages, switching their phagocytic target from leukocytes to erythrocytes, contributing to atherosclerosis.
DOI 10.1101/2023.05.01.538808