JAM-A functions as a female microglial tumor suppressor in glioblastoma
S. M. Turaga, D. J. Silver, D. Bayik, E. Paouri, S. Peng, N. Borjini, S. Stanko, U. Naik, R. A. Keri, J. R. Connor, J. Barnholtz-Sloan, J. B. Rubin, M. Berens, D. Davalos, J. Lathia
This study shows that JAM-A deficiency in female mice increases microglia activation and GBM growth, revealing a sex-specific role for JAM-A in the tumor microenvironment.
bioRxiv · Sep 11, 2019Cancer Biology