J. Lathia

γ-aminobutyric acid receptor B signaling drives glioblastoma in females in an immune-dependent manner

This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

miR-644a is a tumor cell-intrinsic mediator of sex bias in glioblastoma

This study identifies miR-644a as a tumor cell-intrinsic mediator of sex bias in glioblastoma, showing it is more highly expressed in females and its target genes are linked to poorer survival.

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

Iron Inhibits Glioblastoma Cell Migration and Polarization

This study shows that increasing cellular iron content reduces migratory capacity and polarization in human glioblastoma cells, with CDC42 expression being affected.

Tumor cell-intrinsic HFE drives glioblastoma growth

This study shows that HFE promotes glioblastoma growth by regulating iron homeostasis and oxidative stress, with HFE loss inducing apoptosis and extending survival.

The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma

The paper identifies a germline SNP, rs755622, associated with increased leukocyte infiltration in glioblastoma and links it to lactotransferrin expression as a potential biomarker for immune activation.

VRK1 is a Paralog Synthetic Lethal Target in VRK2-methylated Glioblastoma

This study identifies VRK1 as a synthetic lethal target in VRK2-methylated glioblastoma by showing that VRK1 inhibition leads to tumor growth inhibition in xenograft models.

Distinct cell adhesion signature defines glioblastoma myeloid-derived suppressor cell subsets

The paper identifies distinct cell adhesion signatures in glioblastoma myeloid-derived suppressor cell subsets, showing that monocytic MDSCs drive tumor growth through enhanced integrin β1 expression.

Targeting the Cx26/NANOG/Focal Adhesion Kinase Complex via Cell Penetrating Peptides in Triple Negative Breast Cancers

This study demonstrates that a cell-penetrating peptide targeting the Cx26/NANOG/FAK complex inhibits tumor growth and alters NANOG activity in triple-negative breast cancer.

LCK Regulates Homologous Recombination DNA Repair Identifying a New Therapeutic Target for Sensitizing PARP Inhibitors in HR Proficient Ovarian Cancer

This study identifies LCK's role in HR repair in ovarian cancer, showing its inhibition sensitizes HR-proficient tumors to PARP inhibitors.

LPA/PKD-1 signaling promotes development of arteriolar niche that supports self-renewal of breast cancer stem cells and stemness

Single-Cell Analysis of Hyperthermic Intraperitoneal Chemotherapy Treated Tumors Reveals Distinct Cellular and Molecular Responses

This study uses single-cell RNA-seq to analyze tumor responses to HIPEC in ovarian cancer patients, identifying distinct cellular and molecular changes.

Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches

This study identifies distinct lipid metabolism patterns in glioblastoma stem and non-stem cells across different tumor microenvironments, highlighting potential therapeutic targets.

Pretreatment with LCK Inhibitors Chemosensitizes Cisplatin-Resistant Endometrioid Ovarian Tumors

This study shows that pretreatment with LCK inhibitors makes cisplatin-resistant endometrioid ovarian tumors more sensitive to cisplatin, improving cell viability and tumor growth inhibition.

Disruption of the gut microbiota attenuates epithelial ovarian cancer sensitivity to cisplatin therapy

This study shows that antibiotic treatment disrupts the gut microbiome, leading to increased resistance to cisplatin in ovarian cancer models.

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

This study identifies sex-specific roles of MDSC subsets in glioblastoma, showing mMDSCs drive growth in males and gMDSCs in females, with potential therapeutic targets.

Glioblastoma myeloid-derived suppressor cell subsets express differential macrophage migration inhibitory factor receptor profiles that can be targeted to reduce immune suppression

This study identifies differential MIF receptor expression in GBM MDSC subsets and shows targeting M-MDSCs with ibudilast reduces immune suppression.

JAM-A functions as a female microglial tumor suppressor in glioblastoma

This study shows that JAM-A deficiency in female mice increases microglia activation and GBM growth, revealing a sex-specific role for JAM-A in the tumor microenvironment.

Integrin α6β4 is downregulated in mutant IDH1 oligodendrogliomas, promotes glioma growth, and associates with a worse outcome in glioma patients

This study shows integrin α6β4 is downregulated in IDH1 mutant oligodendrogliomas, promotes glioma growth, and is linked to worse patient outcomes.

Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells

This study identifies Rap1a as a conserved regulator of glioblastoma cancer stem cell migration using a combination of Drosophila and human models.

Recasting the cancer stem cell hypothesis: unification using a continuum model of microenvironmental forces

The paper unifies the cancer stem cell and stochastic models using a continuum model of microenvironmental forces, supported by clonogenic assay results.