Author

D. Dingli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

A. Traulsen· 2 shared B. Werner· 2 shared D. Zhou· 1 shared I. Ahmed· 1 shared M. A. Boettcher· 1 shared W. Huang· 1 shared Y. Luo· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 9 mutual co-author links

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2 shared papersEvolutionary Biology

A. Traulsen

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3 papers

Recent·Most cited

Clonal fitness decline in somatic differentiation hierarchies

I. Ahmed, D. Dingli, W. Huang, B. Werner

The paper shows clonal fitness declines over time in somatic differentiation hierarchies, observable in human haematopoiesis and CLL, with a 1/time relationship and equilibrium fitness.

bioRxiv · Sep 27, 2023 · PreprintCancer Biology

The invasion of de-differentiating cancer cells into hierarchical tissues

D. Zhou, Y. Luo, D. Dingli, A. Traulsen

This study uses mathematical models to investigate how de-differentiation can be an adaptive mechanism in cellular hierarchies, deriving thresholds for its emergence based on hierarchy properties and de-differentiation patterns.

bioRxiv · Mar 11, 2019Evolutionary Biology

Replicative cellular age distributions in compartmentalised tissues

M. A. Boettcher, B. Werner, D. Dingli, A. Traulsen

This study examines how progenitor compartments with different self-renewal and differentiation capacities affect replicative cellular age distributions and cancer risk.

bioRxiv · Apr 20, 2018Evolutionary Biology