W. Huang

Constitutive upregulation of transcription factors underlies permissive bradyzoite differentiation in a natural isolate of Toxoplasma gondii.

This paper identifies a Toxoplasma gondii isolate that constitutively expresses bradyzoite regulators and readily differentiates into mature bradyzoites under stress, providing a new in vitro model for studying chronic infection.

Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum

This study investigates meiotic processes in Cryptosporidium parvum by analyzing chromosome segregation and recombination rates using transgenic parasites and in vitro cultures, revealing Mendelian inheritance and high crossover rates.

Complex life cycles and parasite-mediated trophic cascades drive species coexistence and the maintenance of genetic diversity

This study uses an individual-based model to show that parasite-mediated selection influences species coexistence and genetic diversity in predator-prey-parasite systems.

Chloroplast Methyltransferase Homolog RMT2 is Involved in Photosystem I Biogenesis

The paper identifies RMT2 as a chloroplast methyltransferase homolog involved in photosystem I biogenesis in Chlamydomonas reinhardtii through a high-throughput O2 sensitivity screen.

Climate change has desynchronized insect and vegetation phenologies across Europe

The paper examines phenological shifts in European vegetation and herbivorous insects over 34 years, finding that 61.2% have become asynchronous, with vegetation advancing faster than insects.

The Arabidopsis PPR protein EMB1006 interacts with both EMB1270 and CFM2 to facilitate plastid clpP1 intron2 splicing

Cultivation of host-adapted Cryptosporidium parvum and Cryptosporidium hominis using enteroids for cryopreservation of isolates and transcriptomic studies of infection

This paper develops a method to cultivate and cryopreserve Cryptosporidium hominis and C. parvum using enteroids, showing improved transcriptomic responses compared to conventional cell systems.

Mutation divergence over space in tumour expansion

This study quantifies how mutation divergence varies with sampling distance and tumour expansion modes using simulations, showing that mutation rate inference is less accurate with smaller sampling sizes and slower expansion.

Parasite-mediated predation determines the infection in a complex predator-prey system

This study investigates how parasite transmission through trophic interactions affects predator-prey dynamics, showing that stochasticity and infection probabilities influence species coexistence and population composition.

Immune Epitopes of SARS-CoV-2 Spike Protein and Considerations for Universal Vaccine Development

This paper reviews immune epitopes of SARS-CoV-2 Spike protein and discusses their implications for universal vaccine development.

Th2 and Th17-Associated Immunopathology Following SARS-CoV-2 Breakthrough Infection in Spike-vaccinated ACE2-humanized Mice

This study investigates VAERD risks in vaccinated mice following SARS-CoV-2 breakthrough infections, revealing Th2/Th17-driven pulmonary immunopathology.

High-throughput single-cell sorting by stimulated Raman-activated cell ejection

This paper introduces a high-throughput single-cell sorting platform using stimulated Raman-activated cell ejection, achieving high yield and purity in sorting polymer beads, bacteria, fungi, and tissue sections.

Redox Activated Substrates for Enhancing Activatable Cyclopropene Bioorthogonal Reactions

The paper identifies a cyclopropene-quinone pair that significantly enhances reactivity and demonstrates two activation mechanisms for bioorthogonal imaging.

Anti-adipogenic properties of clock activator chlorhexidine and a new derivative

This study identifies chlorhexidine and its derivative CM002 as clock activators with anti-adipogenic properties, showing they inhibit adipogenesis via Wnt pathway activation.

Clonal fitness decline in somatic differentiation hierarchies

The paper shows clonal fitness declines over time in somatic differentiation hierarchies, observable in human haematopoiesis and CLL, with a 1/time relationship and equilibrium fitness.

Negative allosteric modulation of the μ-opioid receptor

This paper identifies a negative allosteric modulator of the μ-opioid receptor that blocks agonist activity and enhances naloxone efficacy, offering potential for safer opioid overdose reversal.

Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway

This study identifies the CD36-PKM2-mtROS pathway as a mechanism by which oxidized LDL disrupts efferocytosis, contributing to atherosclerosis progression.

In-situ Single-Molecule Investigations of the Impacts of Biochemical Perturbations on Conformational Intermediates of Monomeric α-Synuclein

This study uses in-situ single-molecule techniques to identify a partially folded conformation of α-synuclein and shows its sensitivity to biochemical perturbations and drugs.

Adaptive therapy achieves long-term control of chemotherapy resistance in high grade ovarian cancer

This study demonstrates that adaptive therapy reduces chemotherapy resistance in ovarian cancer by exploiting fitness costs of resistant cells, extending survival in mice and correlating with disease burden in patients.

Coordinated inheritance of extrachromosomal DNA species in human cancer cells

This study shows that multiple extrachromosomal DNA species are coordinately inherited in cancer cells through mitotic co-segregation, enabling oncogene cooperation and guiding therapeutic strategies.

Tandemly duplicated MYB genes specifically in the Phaseoleae lineage are functionally diverged in the regulation of anthocyanin biosynthesis

The paper investigates functional divergence of tandemly duplicated MYB genes in soybean, showing they regulate anthocyanin biosynthesis differently in various tissues.

Structural insights into Rad18 targeting by the SLF1 BRCT domains

The paper presents the crystal structure of SLF1tBRCT bound to Rad18 peptide, revealing mechanisms of Rad18 recognition and BRCT-mediated complex assembly.

Structural Basis for Regulated Assembly of the Mitochondrial Fission GTPase Drp1

This paper presents a cryo-EM structure of Drp1 dimer revealing conformational rearrangements that regulate its self-assembly and mitochondrial fission.

Bimodular Architecture of Bacterial Effector SAP05 Drives Ubiquitin-Independent Targeted Protein Degradation

This paper reports the crystal structures of SAP05 complexes and reveals their bimodular architecture enabling ubiquitin-independent targeted protein degradation in eukaryotic cells.

Pyranthiones/Pyrones: Click and Release Donors for Subcellular Hydrogen Sulfide Delivery and Labeling

This paper introduces pyranthiones/pyrones as click and release donors for subcellular H2S delivery, showing enhanced reaction rates and efficient H2S release.

Precision-engineered biomimetics: the human fallopian tube

The paper develops a precision-engineered multi-compartment organoid model of the human fallopian tube validated against a 3D single-cell reference map.

In vivo Ontogeny of human forebrain neural progenitor cell grafts in adult rats: an immunohistological study

This study tracks human neural progenitor cell grafts in adult rats up to 9 months, revealing their migration and differentiation patterns, and highlights their potential for neural repair.

Myocardial IGF2R is a critical mediator of inflammation and fibrosis after ischemia-reperfusion injury

This study investigates the role of IGF2R in myocardial ischemia-reperfusion injury, finding it promotes inflammation and fibrosis and is a potential therapeutic target.

1 Natural Genetic Variation in a Dopamine Receptor is Associated With Variation in Female Fertility in Drosophila melanogaster

This study identifies a dopamine receptor variant linked to female fertility variation in Drosophila melanogaster using genome-wide association and functional validation.

ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathway

This study shows ITK signaling regulates the switch between Th17 and Treg cell lineages via a calcium-mediated pathway, with implications for modulating immune responses.